个人简历

2001.4-2005.3，日本国立山口大学获博士学位（硕博连读）

1994.9-1999.7，中央民族大学获学士学位

2017.1，入选昆明市中青年学术和技术带头人

2015.11，入选云南省中青年学术和技术带头人后备人才

2010.7，遴选为全球最大的菠菜网硕士生导师

 

主要研究方向

疾病分子机制的研究以及疾病相关生物标志物的快速检测

 

实验室成员和在读研究

汪思齐（2014级博士研究生）、李锦秀（2015级博士研究生）、郭丽霞（2014级硕士研究生）、马腾飞（2014级硕士研究生）、刘凤（2015级硕士研究生）、张晓华（2015级硕士研究生）、金莲（2016级硕士研究生）、孙伟杰（2016级硕士研究生）、张才星（2017级硕士研究生）、卢宇勋（2017级硕士研究生）究生）、刘凤（2015级硕士研究生）、张晓华（2015级硕士研究生）、金莲（2016级硕士研究生）、孙伟杰（2016级硕士研究生）、张才星（2017级硕士研究生）、卢宇勋（2017级硕士研究生）

 

教授课程

进化基因组学讲座

 

主要论文

1. Zhao H#, Liu F#, Wu SL, Yang L, Zhang YP*, Li CP*. Ultrasensitive electrochemical detection of Dicer1 3’UTR for the fast analysis of alternative cleavage and polyadenylation. Nanoscale. 2017. 9:4272-4282.

2. Zhao H, Ma TF#, Lin J#, Liu LL, Sun WJ, Guo LX, Wang SQ, Otecko Newton O, Zhang YP*. Identification of valid reference genes for mRNA and microRNA normalisation in prostate cancer cell lines. Scientific Reports. 2018. 8:1949.

3. Zhao H#, Wang SQ#, Guo LX#, Du YL, Liu LL, Ma TF, Otecko NO, Li CP*, Zhang YP*. Fixed differences in the 3’UTR of buffalo PRNP gene provide binding sites for miRNAs post-transcriptional regulation. Oncotarget. 2017. 8(28):46006-46019.

4. Zhao H#, Yang L#, Li YC, Ran X, Ye HZ, Zhao GF, Zhang YQ, Li CP*. A comparison study of macrocyclic hosts functionalized reduced graphene oxide for electrochemical recognition of tadalafil. Biosens Bioelectron. 2017. 89: 361-369.

5. Ye YQ#, Zhao H#, Zhou HJ #, Ren XD #, Liu LL#, Otecko NO, Wang ZB, Yang MM, Zeng L, Hu XT, Yao YG, Zhang YP*, Wu DD*. The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria. Science Bulletin. 2017. 62:820–830.

6. Zhao H, Wang SQ, Qing LL, Liu LL, Zhang YP. Expression of BSE-associated proteins in the CNS and lymphoreticular tissues of cattle and buffalo. Science Bulletin. 2016. 61(17):1377-1383.

7. Yang L, Xie XG, Cai L, Ran X, Li YC, Yin TP, Zhao H*, Li CP*. P-sulfonated calix[8]arene functionalized grapheme as a “turn on” fluorescent sensing platform for aconitine determination. Biosens Bioelectron. 2016. 82: 146-154.

8. Yang L, Ran X, Cai L, Li YC, Zhao H*, Li CP*. Calix[8]arene functionalized single-walled carbon nanohorns for dual-signalling electrochemical sensing of aconitine based on competitive host-guest recognition. Biosens Bioelectron. 2016.83: 347-352.

9. Yang L, Zhao H#, Li YC, Ran X, Deng GG, Zhang YQ, Ye HZ, Zhao GF, Li CP. Indicator displacement assay for cholesterol electrochemical sensing using a calix[6]arene functionalized grapheme-modified electrode. Analyst. 2015. 141: 270-278.

10. Zhao H#, Du YL#, Chen SM, Qing LL, Wang XY, Huang JF, Wu DD, Zhang YP*. The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo. Infect Genet Evol. 2015. 36:531-538.

11. Yang L, Zhao H#, Li YC, Ran X, Deng GG, Xie XG, Li CP*. Fluorescent detection of tadalafil based on competitive host-guest interaction using p-sulfonated calix[6]arene functionalized grapheme. ACS Appl Mater Interfaces. 2015. 7: 26557-26565.

12. Yang L#, Zhao H#, Deng GG, Ran X, Li YC, Li CP* Immunosensor for prostate-specific antigen using Au/Pd@flower-like SnO2 as platform and Au@mesoporous carbon as signal amplification. RSC Adv. 2015. 5: 74046-74053.

13. Yang L#, Zhao H#, Fan SM, Zhao GF, Ran X, Li CP.* Electrochemical detection of cholesterol based on competitive host–guest recognition using a β-cyclodextrin/poly(N-acetylaniline)/ graphene-modified electrode. RSC Adv. 2015. 5: 64146-64155.

14. Liu LL#, Zhao H#, Ma TF, Ge F, Chen CS, Zhang YP*. Identification of valid reference genes for the normalization of RT-qPCR expression studies in human breast cancer cell lines treated with and without transient transfection. PLoS ONE. 2015. 10(1): e0117058.

15. Yang L#, Zhao H#, Li CP*, Fan S, Li B. Dual β-cyclodextrin functionalized Au@SiC nanohybrids for the electrochemical determination of tadalafil in the presence of acetonitrile. Biosens Bioelectron. 2015. 64: 126-130.

16. Yang L#, Zhao H#, Fan S, Deng S, Lv Q, Lin J, Li CP* Label-free electrochemical immunosensor based on gold-silicon carbide nanocomposites for sensitive detection of human chorionic gonadotrophin. Biosens Bioelectron. 2014. 57: 199-206.

17. Yin CY, Yang L, Zhao H*, Li CP*. Improvement of antioxidant activity of egg white protein by phosphorylation and conjugation of epigallocatechin gallate. Food Res Int. 2014. 64: 855-863.

18. Li CP*, He Z, Wang X, Yang L, Yin C, Zhang N, Lin J, Zhao H*. Selenization of ovalbumin by dry-heating in the presence of selenite: effect on protein structure and antioxidant activity. Food Chem. 2014. 148: 209-217.

19. Wang SQ, Zhao H*, Zhang YP. Advances in research on Shadoo, Shadow of prion protein. Chinese Sci Bull. 2014. 59(9): 821–827.

20. Zhao JP#, Zhao H#, Wang X, Huang R, Enomoto H, He Z, Li CP*. Characteristics and enhanced antioxidant activity of egg white protein selenized by dry-heating in the presence of selenite. J Agric Food Chem. 2013. 61: 3131-3139.

21. Huang R, Li CP, Chen D, Zhao G, Cheng W, Zhang Y, Zhao H*. Preparation of phosphorylated starch by dry-heating in the presence of pyrophosphate and its calcium-phosphate solubilizing ability. J Food Sci & Technol. 2013. 50: 561-566.

22. Zhao H#, Liu LL#, Du SH, Wang SQ, Zhang YP*. Comparative analysis of the Shadoo gene between cattle and buffalo reveals significant differences. PLoS One. 2012. 7(10): e46601.

23. Zhao H, Mitsuiki S*, Takasugi M, Sakai M, Goto M, Kanouchi H, Oka T. Decomposition of insoluble and hard-to-degrade animal protein by enzyme E77 and its potential applications. Appl Biochem Biotechnol. 2012. 166(7):1758-1768.

24. Zhao H, Wang XY, Zou W, Zhang YP*. Prion protein gene (PRNP) polymorphisms in native Chinese cattle. Genome. 2010. 53:138-145.

25. Li CP, Enomoto H, Hayashi Y, Zhao H*, Aoki T. Recent advances in phosphorylation of food protein: A review. LWT-Food Sci. & Technol. 2010. 43:1295-1300.

26. Wang XY, Li NZ, Yu L, Zhao H, Zhang YP*. Duplication and functional diversification of pancreatic ribonuclease (RNASE1) Gene. Chinese Sci Bull. 2010. 55: 2-6.

27. Zhao H, Wang XY, Zhang YP*. The indel polymorphisms of prion protein gene (PRNP) in Chinese yak. Anim Genet. 2009. 40: 575-576.

28. Qing LL, Zhao H*, Liu LL. Progress on low susceptibility mechanisms of transmissible spongiform encephalopathies. Zoological Research. 2014. 35(5): 436-445. 2

29. Mitsuiki S, Zhao H, Matsumoto D, Sakai M, Moriyama Y, Furukawa K, Kanouchi H, Oka T. Degradation of PrPSc by keratinolytic protease from Nocardiopsis sp. TOA-1. Biosci Biotechnol Biochem. 2006. 70:1246-1248.

30. Zhao H, Doi H, Kanouchi H, Matsuura Y, Mohri S, Nonomura Y, Oka T. Alkaline serine protease produced by Streptomyces sp degrades PrPSc. Biochem Biophys Res Comm. 2004. 321: 45-50.

31. Zhao H, Minamiguchi K, Doi H, Kinoshita N, Kanouchi H, Oka T. Recombinant alkaline serine protease II degrades PrPSc. In Vitro Cell Dev-An. 2004. 40: 293-296.