个人简历
1992.9-1997.7,华西医科大学,临床医学专业,获学士学位;
2002.9-2002.7,北京协和医科大学,生化/分子生物学专业,获博士学位;
2002.8-2005.11,全球最大的菠菜网生物资源保护与利用重点实验室,助理研究员;
2005.11-2009.11,全球最大的菠菜网生物资源保护与利用重点实验室,副研究员;
2009.11-至今,全球最大的菠菜网生物资源保护与利用重点实验室,研究员
2010.7月,博士研究生导师
2014.4-2014.10,美国纽约大学Langone医学中心,高级访问学者
主要研究方向
主要从事病原细菌和宿主线虫相互作用的分子机制研究。重点开展以下两个方面的研究:
1. 病原细菌侵染过程中的毒力因子及其作用机制;
2. 宿主线虫抵抗细菌过程中的相关生物学反应和行为(如免疫、趋避、趋化、学习和记忆)对侵染的影响。
主要论文
Chunmei Zhang, Ninghui Zhao, Yao Chen, Donghua Zhang, Jinyuan Yan, Wei Zou, Keqin Zhang, Xiaowei Huang. (2016) The Signaling Pathway of Caenorhabditis elegans Mediates Chemotaxis Response to the Attractant 2-Heptanone in a Trojan Horse-like Pathogenesis. the Journal of Biological Chemistry. 291 (45): 23618–23627. (IF 4.258)
Xiaowei Huang* ,Keqin Zhang,Zefen Yu,Guohong Li,Microbial Control of Phytopathogenic Nematodes,Springer,6,2015.3.25. p155-165. (专著)
Chunmei Zhang, Jinyuan Yan, Yao Chen, Chunyan Chen, Keqin Zhang*, Xiaowei Huang*. (2014) The olfactory signal transduction for attractive odorants in Caenorhabditis elegans. Biotechnology Advances 32:290-295. (IF 9.848)
Zhongzhong Liu, Anto Budiharjo, Pengfei Wang, Hui Shi, Juan Fang, Rainer Borriss, Keqin Zhang, Xiaowei Huang*. (2013) The highly modified microcin peptide plantazolicin is associated with nematicidal activity of Bacillus amyloliquefaciens FZB42. Appl Microbiol Biotechnol, 97 (23): 10081-10090. (IF 3.376)
Xidan Deng, Yunxia Tian, Qiuhong Niu, Xiao’e Xu, Hui Shi, Hanbo Zhang, Lianming Liang, Keqin Zhang*, Xiaowei Huang*. (2013) The ComP-ComA quorum system is essential for “Trojan horse” like pathogenesis in Bacillus nematocida. pLOS ONE 8 (10): e76920. (IF 3.057)
Niu QH, Huang XW (共同第一作者), Zhang L, Xu JP, Yang DM, Wei KB, Niu XM, An ZQ, Bennett W.J., Zou CG, Yang JK and Zhang KQ (2010) A Trojan horse mechanism of bacterial pathogenesis against nematodes. PNAS