个人简历
    

1991-1995 河北大学环境生物学专业   学士

1998-1998 中科院昆明动物研究所动物学专业   硕士

1998-2001 中科院环境生态研究中心环境生化专业   博士

2002-2004 美国马里兰大学 分子遗传学专业  博士后

2004-2009 美国范德堡大学癌症研究中心  研究科学家

2010-至今 全球最大的菠菜网 生化与分子生物学  教授

主要研究方向

本实验室关注肿瘤中的相关调控机理，以细胞株及临床病理样品为材料，集中关注Bcl-2家族在细胞凋亡及自噬中的调控作用及与线粒体代谢的关系。

实验室成员

余敏 副教授（研究方向：肿瘤微环境与细胞能量代谢的关系）

林洁 副教授（研究方向： 抗肿瘤药物的作用机制研究）

丁磊 讲师

吕琦 实验师

在读研究生

 
主要论文

1. Lei Ding, Huan Gu, Zhenwei Lan, Qingchun Lei, Wenxue Wang, Jie Lin, Min Yu and Qinghua Cui^* 2019. Down-regulation of cyclooxygenase-1 stimulates mitochondrial apoptosis through NF-kB signaling pathway in Colorectal Cancer Cells. Oncology Reports, 41: 559-569.

2. Lei Ding^†, Zhenwei Lan^†, Xianhui Xiong, Hongshun Ao, Yingting Feng, Huan Gu, Min Yu, Qinghua Cui^* 2018. The dual role of microRNAs in colorectal cancer progression. Int. J. Mol. Sci.. 19(9):2791                                                           

3. Kun YAO, Xu-feng FU, Xing DU, Yan LI, Shan-shan YANG, Min YU, Qing-hua CUI*. 2018. PGC-1α coordinates with Bcl-2 to control the cell cycle in U251 cells through reducing ROS. JZUS B, 19(6): 415-424

4. Da-Jian He, Ling Wang, Zhi-Bi Zhang, Kun Guo, Jing-Zheng Li, Xie-Chao He, Qing-Hua Cui*, Ping Zheng*. 2018. Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes. Zoo. Res. 39(6): 1-10.

5. Ran Wei, Qin Yang, Bing Han, Yan Li, Kun Yao, Zexi Chen, Jiaqi Zhou, Qinghua Cui^*. 2017. MicroRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. Oncotarget DOI: 10.18632

6. Xing Du, Xufeng Fu, Kun Yao, zhenwei Lan, Hui Xu, Qinghua Cui*, Elizabeth Yang*. 2017. Bcl-2 delays cell cycle through mitochondrial ATP and ROS. Cell Cycle. 16(7): 707-713

7. Xu-feng Fu, Kun Yao, Xing Du, Yan Li, Xiu-yu Yang, Min Yu, Mei-zhang Li, Qing-hua Cui*. 2016. PGC-1a regulates the cell cycle through ATP and ROS in CH1 cells. JZUS B, 17 (2):136-146.

8. Wei Xu, Zexi Chen, Naeem Ahmed, Bing Han, Qinghua Cui* and Aizhong Liu*. 2016. Genome-Wide Identification, Evolutionary Analysis, and Stress Responses of the GRAS Gene Family in Castor Beans. Int. J. Mol. Sci. 17, 1004;

9. W. Wang, Y. Ye, J. Li, X. Li, X. Zhou, D. Tan, Y. Jin, E. Wu, Qinghua.Cui and M. Wu. 2014. Lyn Regulates Cytotoxicity in Respiratory EpithelialCells Challenged by Cigarette Smoke Extracts. Curr. Mol. Med. 14,1-10

10. Wei Xu#, Qinghua Cui#, Fei Li, Aizhong Liu*. 2013. Transcriptome-wide identification and characterization of MicroRNAs from castor bean (Ricinus communis L.). PLOS ONE, 8 (7): e69995.

11. Qinghua Cui, Mayda Valentin, Yelena Janumyan, Elizabeth Yang. 2009. Bax-/- bak-/- cells exhibit p27Thr198 phosphorylation and autophagy. Autophagy 5 (2): 263-264.

12. Yelena Janumyan#, Qinghua Cui#, Ling Yan, Courtney G. Sansam, Elizabeth Yang. 2008. Go function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation, revealing a novel role of BAX and BAK in quiescence regulation. JBC, 283: 34108; 34120.

13. Ling Yan, Viviana A. Lavin, Leta R. Moser, Qinghua Cui, Cindy Kanies, and Elizabeth Yang. 2008. PP2A Regulates the Pro-apoptotic Activity of FOXO1. JBC 283: 7411; 7420.