个人简历
研究方向
本课题组专注研究转录和非经典翻译过程中的调控分子机理，从而助力寡核苷酸创新药的开发。目前课题组有助理研究员1人、博士生5人、硕士生10人、科研助理1人。具有完备的基因组学、各类转录翻译组学和蛋白质组学的分析能力。本课题组通过紧密结合生化分子生物学与生物信息学，旨在通过理解人类致病基因的转录和翻译过程中的调控分子机理，从而助力寡核苷酸创新药的开发。课题组现主持3项国家自然科学基金和多项省级基金，在Molecular Cell, Genes & Development, PNAS, Nucleic Acid Research、eLife等主流杂志发表论文19篇，被引1500次。
教育经历
1995-1999, 中国农业大学（中国北京） 理学学士
1999-2002, 中国农业大学（中国北京） 理学硕士
2003-2009, 英属哥伦比亚大学（加拿大温哥华） 哲学博士 (导师： Beverley R. Green 教授)
2010-2017, 德克萨斯大学西南医学中心（美国达拉斯） 博士后、讲师（合作导师：Yi Liu教授）
发表文章
1. Chengcheng Zhang, Yuan Tian, Shuang Song, Lu Zhang, Yunkun Dang*, and Qun He*, H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading，Nucleic Acids Res. (2022) 50(7): 3852–3866.
2. Fangzhou Zhao, Zhipeng Zhou, Yunkun Dang, Hyunsoo Na, Catherine Adam, Anna Lipzen, Vivian Ng, Igor V Grigoriev , Yi Liu. Genome-wide role of codon usage on transcription and identification of potential regulators, Proceedings of National Academy of Science of USA (2021) 118(6):e2022590118.
3. Xueliang Lyu, Qian Yang, Lin Li, Yunkun Dang, Zhipeng Zhou, She Chen, Yi Liu， Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape，PLoS Genet. (2020) Jun 1;16(6):e1008836.
4. Qian Yang, Chien-Hong Yu, Fangzhou Zhao, Yunkun Dang, Cheng Wu, Pancheng Xie, Matthew S. Sachs, Yi Liu, eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons. Nucleic Acid Research (2019): DOI: 10.1093/nar/gkz710
5. Jingjing Fu, Yunkun Dang, Christopher Counter, Yi Liu, Codon usage regulates human KRAS expression at both transcriptional and translational levels. Journal of Biological Chemistry, (2018) DOI：10.1074/jbc.RA118.004908
6. Zhipeng Zhou#, Yunkun Dang#*, Mian Zhou, Haiyan Yuan, Yi Liu*, Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation. ELife (2018) 7:e33569
7. Xiao Liu, Yunkun Dang, Toru Matsu-ura, Yubo He, Qun He, Christian I. Hong, Yi Liu, DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition. Molecular Cell (2017) 67:1-11
8. Yunkun Dang#, Jiasen Cheng#, Xianyun Sun, Zhipeng Zhou, Yi Liu. Antisense transcription licenses nascent transcripts to be recognized by ERI-1 to mediate transcriptional gene silencing. Genes & Development, (2016) 30:2417-32.
9. Zhipeng Zhou#, Yunkun Dang#, Mian Zhou, Lin Li, Chien-Hung Yu, Jingjing Fu, She Chen, and Yi Liu. Codon Usage is an Important Determinant of Gene Expression Levels Largely Through its Effects on Transcription. Proceedings of National Academy of Science of USA (2016) E6117-E6125.
10. Chien-hung Yu#, Yunkun Dang#, Zhipeng Zhou#, Cheng Wu, Fangzhou Zhao, Matthew S. Sashs, Yi Liu. Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding. Molecular Cell (2015) 59:744-54（封面文章，Trend Biochem Sci (2015) 40:717-8专评）
11. Yunkun Dang, Zhenyu Zhang, Yi Liu. Small RNA-mediated gene silencing in Neurospora. Fungal RNA Biology, page 269-89, Springer International Publishing (2014) (book chapter)
12. Yunkun Dang, Liande Li, Wei Guo, Zhihong Xue, Yi Liu. Convergent transcription induces dynamic DNA methylation at disiRNA loci. PLoS Genetics (2013) 9(9): e1003761
13. Chang Ying Teng, Yunkun Dang, Jillian C. Danne, Ross F. Waller, Beverley R. Green. Genes of Dinoflagellates Are Transcribed by a Nuclear-Encoded Single-Subunit RNA Polymerase. PLoS One (2013) DOI: 10.1371/journal.pone.0065387
14. Yunkun Dang, Qiuying Yang, Zhihong Xue, Yi Liu. RNA interference in fungi: pathways, functions, and applications. Eukaryotic Cell (2011) 10: 1148-1155
15. Yunkun Dang, Beverley R. Green, Long transcripts from dinoflagellate chloroplast minicircles suggest "rolling circle" transcription. Journal of Biological Chemistry (2010) 285: 5196-5203.
